04/2016 - RSP Amino Acid notes - RSP Amino Acids, LLC

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RSP Amino Acids Note No. 1 about 2,6-dimethyltyrosine (DMT)

Published by in Tyrosine ·
2056, 2056-f, 2056-b, 2054, 2054-f, 2054-b (2S) and (2R), aka DMT, Tyr(2,6-dimethyl), 2S- or 2R-Amino-3-(4-hydroxy, 2,6-dimehtylphenyl)propanoic acid, 26DMY or 26DMy

RSP introduced 2,6-dimethyltyrosine commercially for pre-clinical research at the IRCM in Canada in 2000.  It is active in organic synthesis for medicinal chemistry, pain, and cardiovascular research boosting respiration in heart tissue.  We offer 2,6-dimethyltyrosine in the purest form (99+%, 99+% ee 2S, less than 0.5% 2R, measured 0.25%) available.  The FDA thinks this is important because formula toxicity has been attributed to enantiomeric impurities.  For this reason, we went on to develop and distribute the purest fom of the opposite enantiomer (2R-isomer, 2054) so that research can examine its effect in their drug leads.  Our customers use our material in clinical studies because a less than a 0.5% impurity of the opposite enantiomer can destroy their program in animal and human studies.  The hallmark of chiral medicine is potency, therefore you must rule out toxic effects as proof for approval.

The product is available from grams to kilograms or larger at these specifications.  This molecule of the week has a 20% discount for the next 30 days (6/15/2016).  Contact us for a quote, to modify it chemically or to build it into your drug candidate.  We are highly skilled at incorporaton of our analogues as terminnal caps, in sequence with normal or modified backbones, in linear, cyclic peptides and peptidomimetics.  

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